Present work is devoted to service-oriented systems problems. Particularly, medical web-services are discussed. Information technologies classification in medicine and urgency of web-services using in medicine are formulated. Unique service-oriented pharmacological system development is proposed. The making goal, architecture of given system and its functions are described. Interconnection of system functions and medicine data is given as schema. Operations of logical derivations which are determinated on clear rules based on the analysis of Boolean matrixes are proposed for implementation of given interconnection. Designing any web-service one should takes into account its dependability. Therefore the analysis of web-services dependability intermediums. Dependable service-oriented architecture and system diversity models, provided its dependability, were developed. Experimental and also further searches of service-oriented pharmacological system "Medicine" are considered.