The paper discusses importance of assessment of interference degree for various attributes of safety-critical systems, as well as proposes applicable metrics. Also, the paper presents an approach to analysis of safety-critical systems. Such approach relies on performance of gap analysis and consideration of influence of human, technique and tool. The approach is applicable to various safety-critical systems, including complex instrumentation and control systems and FPGA-based systems. Keywords: safety-critical system, instrumentation and control, analysis, assessment, attribute, development life cycle.