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Автор: Familoni Babajide, Abell Thomas, Bhaskar Sudhir, Voeller Guy, Blair Stephanie
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Анотація:
Background: Electrical stimulation has been successfully employed to treat diseases involving electro-pathology in the heart, skeletal muscles, and the brain, but not in the GI tract. Aim: This study examined the clinical feasibility and efficacy of GES in treating patients with severe gastroparesis. Methods: Nausea, vomiting, GEA, and liquid and solid gastric emptying were monitored in eleven patients with refractory gastroparesis at baseline and after one week of continuous electrical stimulation administered at 12 cycles/min. Eight patients were subsequently implanted with permanent stimulation devices. Follow-up studies were conducted after 1, 3, 6, and 12 mo. of stimulation. Results: After oneweekof stimulation, patients’ quantifiedsymptoms of nausea and vomiting decreased significantly, and liquid emptying and GEA improved. This improvement was maintained over time in the patients who continued to receive stimulation. Emptying of solids showed progressive improvement that became significant
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